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Nasopharyngeal carcinoma (NPC)

LiFu Hu

In this project we study the impact of EB-viral genes that are expressed in NPC, particularly latent membrane protein 1 (LMP 1) and latent membrane protein 2 (LMP 2). Their effects on signal transduction and cell cycle are studied in in vitro model epithelial systems. With two-hybrid systems interacting proteins are described. In tissues we also study the interaction of the infected cells with infiltrating lymphocytes. In another project we work with the genetics of NPC.

The members of the NPC-group are: LiFu Hu, researcher; Shao Jianyong, visiting scientist; Xiang Ningzhang, graduate student; Bach Khanh Hoa, visting scholar; and until recently hai Huang and Qiang Qui.

Karolinska Institutet, MTC, Box 280, SE-171 77  Stockholm
Visitor adress: KI Campus, Theorells väg 3, room F452, Solna
Phone: +46-8-728 62 62, Fax: +46-8-31 94 70

Last update: 2000-08-24 by Hong Zou

NPC is one of the most common malignancies in certain geographical regions as in Greenland (31/cases /105 inhabitants / year) and Southern China ( 42 cases /105 inhabitants /year) with the highest incidence in the world , although it is rare in other countries (0.6 cases /105 /year in Sweden. Such a pronounced, uneven distribution and the high rate of familial clustering of this cancer strongly suggest that environmental risk factors, including the EBV infection, cooperate with the genetically susceptible background in the high risk populations.
LiFu Hu