Publications 1997-2000

Falk, K., Zou, Jie-Zhi, Lucht, E., Linde, A., Ernberg, I (1997). Direct identification by PCR of EBV subtypes and variants in clinical samples. J. Med.Virol. 51, 355-363.

Laytragoon-Lewin, N., Chen, F., Avila-Carina, J., Klein, G., Mellstedt, H. (1997) Epstein-Barr virus (EBV) gene expression in lymphoid B cells during acute infectious mononucleosis (IM) and clonality of the directly growing cells. Int J Cancer, 71, 345-349, 1997(Chen, F �r doktorand i min grupp)

Falk, K., Szekely, L., Aleman, A., and Ernberg, I. (1998). Specific methylation patterns in two control regions of Epstein-Barr virus latency: the LMP 1-coding upstream regulatory region and an origin of DNA replication (oriP). J. Virol. 72, 2969-2974.

Falk, K.I., and Ernberg, I. Demethylation of the Epstein-Barr virus origin of lytic replication and of the immediate early gene BZLF1 is DNA replication independent. Archives of Virology. 144(11):2219-27 (1999)

Szeles, A., Falk, K.I., Imreh, S and Klein, G. Visualization of alternative EBV expression programs by FISH at the cell level. J.Virology. 73: 5064-5069 (1999).

Rajnavolgyi E, Nagy N, Thuresson B, Dosztanyi Z, Simon A, Simon I, Karr RW, Ernberg, I., Klein, E., Falk, K.I A repetitive sequence of Epstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4(+) T lymphocytes. Int Immunol Mar;12(3):281-93 (2000).

Holmgren.L., Szeles, A., Rajnav�lgyi, E., Folkman, J., Klein, G., Ernberg, I., Falk, K. (1999). Horizontal transfer by the uptake of apoptotic bodies. Blood, 11, 3956-3963

Gustafsson, A, Levitsky, V., Zou, JZ, Frisan, T, Dalianis, T, Ljungman, P, Ringden, O, Winiarski, J, Ernberg, I, Masucci, M. (2000). Epstein-Barr virus load in bone marrow transplant recipients at risk to develop posttransplant lymphprolferative disease:prophylactic infusion of EBV-specific cytotoxic T-cells. Blood, 95, 807-14

Li, Shun-Cheng, Gish, G., Yang, D., Coffey, A.J., Forman-kay, J.D., Ernberg, I., Kay, L.E., Pawson, T. (1999) Novel model of ligand binding by the SH 2 domain of the human XLP diseae gene product SAP/SH32D1A. Current Biology 9; 1355-1362.

Ehlin-Henriksson, B., Zou, J,-Z., Klein, G. And Ernberg, I. (1999) Epstein-barr virus genomes are found predominantly in IgA-postive B cells in the blood of healthy carriers. Int. J. Cancer 83, 50-54.

Ernberg, I. Burkit�s lymphoma and malaria. In Malaria (Ed. M Wahlgren&P.Perlmann). Ch. 13, 379-99.

Zabarovsky, E.R., Gizatullin, R., Pdowski, R.M., Zabarovska, V.V., Xe, L., Muravenko, O.V., Kozyrev, S., Petrenko, L., Skobeleva, N., Li, Jingfeng, Protopov, A., Kashuba, V., Ernberg, I., Winberg, G., Wahlestedt, C. (2000), NotI clones in the analysis of the human genome. Nucl Acids Res, 28, 7, 1635-1639.

Zabarovska, V.V., , Li, Jingfeng, Muravenko, O., Fedorova, L., Braga, E., Ernberg, I., Wahlestedt, C., Klein, G., Zabarovsky, E.R. (2000). CIS-cloning of identical sequences between two complex genomes. Chromosome Research 8, 77-84.

Johnson., R.L., Stak, M., Hazlewood, S.A., Honess, M., Blackmore, C.G., Hu, L-F., and Rowe, M. (1998) The 30 bp deletion in Chinese variants of the Epstein-Barr virus LMP1 gene is not the major effector of fuctional differences between LMP 1 variants in human lyphocytes. Virology, in press.

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Academic theses

Friis, A.M.C. (1997). Epstein-Barr virus infection in the immunosuppressed: icreased number of infected cells and genetic variation. Licentiat thesis, Karolinska Institutet, KI repro, 1-53.

Falk, K. (1997). Epstein-Barr virus gene methylation and variation inn latency. Academic thesis, Karolinska Institutet, Repro Print, Stockholm, 1-41.

Bernestr�m, J. (2000). A method for identification of transcription factors involved in the latent replication of Epstein-Barr virus. Biomedicine Report, Karol Inst.

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Manuscripts

Gosta Winberg1, Liudmila Matskova1, Fu Chen1, Gerald Gish2, Robert Ingham2, Ingemar Ernberg1, and Tony Pawson2,3,*The LMP2A protein of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B cell tyrosine kinases.

Shao, J.-Y., Huan, X.-M., Yu, X.-J., Huang, L.X., Wu, Q.-L., Xia, J.-C., Wang, H.-Y., feng, Q.-S., Ernberg, I., Hu, L.-F., Zeng, Y.-X. Genetic alteration in Nasopharyngeal carcinoma: Loss of heterozygosity, Epstein-Barr virus Infection and clinical outcomes.

Shao, J.-Y., Wang, H.-Y., Huang, X.-M., Feng, Q.-S., Huang, P., Feng, B.J., Huang, L.X., Yu, X.-J., Li, J.-T., Hu, L.-F., Ernberg, I., Zeng, Y.-X. Alleloptype specific analysis of sporadic primary Nasopharyngeal carcinoma.

Matskova, L., Ernberg, I., Pawson, T. Winberg, G. Acylation, raft microdomain localization and a C-terminal clustering motif in the EBV LMP2a protein.

Friis, A.C.M, Katarina Gyllensten1), B�rje �kerlund1), Anna Aleman, and Ingemar Ernberg* Epstein-Barr virus (EBV) genome load in HIV-1 positive patients with documented asymptomatic infection longer than 10 years and documented symptomatic seroconversion

Friis, Anna M.C. , Anna Aleman, Jan Albert1), B�rje �kerlund2), Viveca Holmberg3), and Ingemar Ernberg* Increased frequency of Epstein-Barr virus (EBV) genomes in B lymphocytes from HIV-1 infected patients as detected by semi-quantitative, nested PCR Friis, Anna M.C. , B�rje �kerlund1),, G�ran Bratt2),, Anna Aleman, Eric Sandstr�m2), and Ingemar Ernberg* Epstein-Barr virus (EBV) genome load in HIV-1 positive patients is affected by rgp-160 vaccination or prehistory of symptoms upon primary infection

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